mcp-opentargets

Open Targets MCP — disease/target/drug knowledge graph.

Part of Pipeworx — an MCP gateway connecting AI agents to 1356+ live data sources.

Tools

| Tool | Description | |------|-------------| | target | "Drug target profile for [gene]" / "is [gene] a druggable target" / "[gene] target info" / "target ID [ENSG...]" — fetch a drug-target profile (Open Targets uses Ensembl gene IDs as target identifiers). Returns approved symbol, name, biotype, protein IDs, pathways, synonyms. Use for target characterization in drug discovery. | | disease | "Disease profile for [EFO_N]" / "look up disease [ID]" — fetch a disease profile from Open Targets by EFO (Experimental Factor Ontology) ID. Returns name, description, therapeutic areas, ontology cross-refs. Pair with disease_associations to find drug targets for the disease. | | drug | "Drug info for [ChEMBL ID]" / "look up [drug] target info" / "[CHEMBL...] mechanism" — fetch a drug profile from Open Targets by ChEMBL ID. Returns name, mechanisms of action, indications, target genes, trade names, clinical-trial phase. Use for drug research, mechanism queries. | | search | "Find [disease / drug / gene target]" / "Open Targets lookup for [name]" / "what's the Open Targets ID for [X]" — text search across diseases, drug targets, and drugs in the Open Targets Platform (the leading drug-discovery knowledge graph). Returns ranked matches with their canonical IDs (ENSG... for targets, EFO_... for diseases, CHEMBL... for drugs). Use first to find IDs, then call target/disease/drug for details. | | target_associations | "What diseases is [gene] involved in" / "diseases associated with [target]" / "what does [gene] cause" — top disease associations for a drug target (Ensembl gene ID), scored by integrated Open Targets evidence (genetics, expression, animal models, drugs, literature, pathways). Use to triage what diseases a candidate target might address. | | disease_associations | "Best drug targets for [disease]" / "what genes are linked to [condition]" / "druggable targets in [disease]" — top drug-target candidates for a disease (EFO ID), scored by integrated evidence. Use for target discovery in a therapeutic area. | | target_known_drugs | "What drugs target [gene]" / "approved drugs against [target]" / "clinical-trial drugs for [gene]" — drugs that have been clinically tested or approved against a drug target (Ensembl gene ID). Returns drug names, mechanisms, indications, clinical trial phases. Use for competitive landscape / drug-repositioning queries. |

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "opentargets": {
      "url": "https://gateway.pipeworx.io/opentargets/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 1356+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Opentargets data" })

The gateway picks the right tool and fills the arguments automatically.

More

• All tools and guides
• pipeworx.io

License

MIT