clinical-trial-design MCP server

TypeScript MCP server that exposes the ClinicalTrialDesign R package as 13 trial-design tools over stdio. One Rscript subprocess per tool call, JSON roundtrip, ~300 ms per call + R compute. Covers Phase 2 and Phase 3 confirmatory designs.

Tools

See the top-level README and SMOKE.md for the full tool surface and working prompts.

Build

npm install
npm run build   # -> dist/index.js

The server is wired from the top-level plugin.json:

"mcpServers": { "clinical-trial-design": { "command": "node", "args": ["mcp-server/dist/index.js"] } }

Smoke pass

npm run build
node scripts/smoke.mjs

Expected: 13 pass / 0 fail / 13 total. The R sources are loaded directly by inst/launcher.R; no remotes::install_local step is required.

Environment

• DESIGNR_RSCRIPT — full path to Rscript if not on PATH.
• DESIGNR_LAUNCHER — full path to launcher.R if you need to override the default.

Layout

src/
  index.ts              # McpServer + stdio transport; registers 13 tools
  r-bridge.ts           # spawns Rscript, JSON roundtrip, 60s timeout
  tools/
    common-schemas.ts   # shared zod fragments
    fixed-*.ts          # 6 fixed-sample tools
    gs-*.ts             # 4 group-sequential tools
    validate-benchmark.ts
    verify-design.ts
    design-report.ts
scripts/
  smoke.mjs             # programmatic 13-tool smoke pass