TruthStack MCP Server

Structured supplement interaction and evidence data for AI agents via the Model Context Protocol.

TruthStack provides machine-readable reference data about dietary supplements and their documented interactions with prescription medications. Instead of relying on LLM training data — which frequently hallucinates supplement information — your agent calls TruthStack for structured, cited evidence from published literature and FDA adverse event reports.

Important: This is informational reference data only. It is not medical advice, not a medical device, and not intended to diagnose, treat, cure, or prevent any disease. Always consult a healthcare provider before making changes to supplements or medications. Our database covers a growing set of compounds and may not be exhaustive.

What It Returns

| Tool | What It Returns | When to Use | |------|----------------|-------------| | check_interactions | Evidence on supplement + medication combinations: reported signals, CYP pathway data, evidence balance | User mentions supplements + meds together | | search_compounds | Fuzzy name resolution (584 aliases, handles misspellings and brand names) | Need to resolve messy input ("mag gly", "KSM-66") | | get_compound_info | Full compound profile + all documented interactions | Deep dive on a specific supplement | | explain_interaction | Human-readable explanation: mechanism, evidence summary, published sources | User asks "why might this be a concern?" | | get_evidence_balance | Raw evidence: FAERS report counts, CYP data, research grades, evidence balance | Need to cite sources or provide provenance |

Data Sources

• FDA FAERS — 805 adverse event reporting signals from pharmacovigilance data
• FDA Drug Labels — CYP450 pathways, contraindications, botanical warnings
• PubMed / ClinicalTrials.gov — 220 research findings with evidence grading
• 584 compound aliases — misspellings, brand names, abbreviations, product forms

Quick Start

1. Get API Key

Contact [email protected] or visit truthstack.co

2. Install

git clone https://github.com/TruthStack1/truthstack-mcp.git
cd truthstack-mcp
npm install

3. Configure Claude Desktop

Edit ~/.claude/claude_desktop_config.json:

{
  "mcpServers": {
    "truthstack": {
      "command": "node",
      "args": ["/path/to/truthstack-mcp/server.js"],
      "env": {
        "VAULT_API_URL": "https://api.truthstack.co",
        "VAULT_API_KEY": "your-api-key"
      }
    }
  }
}

Restart Claude Desktop. You'll see TruthStack tools available in the tool picker.

4. Try It

Ask Claude: "What does published research say about taking ashwagandha with sertraline?"

Claude will call check_interactions and return structured evidence including FDA adverse event report counts and CYP pathway data.

REST API

Every MCP tool maps to a REST endpoint:

| MCP Tool | REST Endpoint | |----------|--------------| | check_interactions | POST /api/interactions/check | | search_compounds | GET /api/compounds/search?q={query} | | get_compound_info | GET /api/compounds/{id} | | explain_interaction | Composite endpoint | | get_evidence_balance | Composite endpoint |

Base URL: https://api.truthstack.co · Auth: X-API-Key header · Docs: https://api.truthstack.co/docs

Intended Use & Limitations

• This is a reference data API, not a medical device or clinical decision support system
• Returns structured summaries of published research and adverse event reporting data
• Not exhaustive — our database covers a growing but incomplete set of compounds and interactions
• Cannot see your full medical history — results reflect only the substances you specify
• Does not diagnose, prescribe, or recommend treatments
• Does not replace pharmacists, physicians, or institutional drug interaction systems
• Outputs should be presented to end users with appropriate context and limitations

System Message Guidance

If building a health-aware agent, consider including guidance like:

You have access to TruthStack reference data tools. When users ask about
supplement and medication combinations, use check_interactions to look up
published evidence rather than relying on training data alone.

When presenting results:
- State what the evidence shows, not what is "safe" or "unsafe"
- Mention FDA adverse event report counts when available
- Note CYP pathway considerations
- Always recommend discussing findings with a healthcare provider
- Make clear this is reference data, not medical advice
- Use explain_interaction when users want to understand the evidence

Contributing

We're looking for:

• Integration partners — building a health-aware AI agent? Get free API access
• Compound contributions — know of missing supplement aliases or interactions? Open an issue
• Framework examples — help us add examples for CrewAI, AutoGen, LlamaIndex

License

MIT

Contact

• API access: [email protected]
• Website: truthstack.co
• API docs: api.truthstack.co

TruthStack provides structured reference data about dietary supplements for informational and educational purposes only. It does not provide medical advice, diagnosis, or treatment. Not a medical device. Not cleared or approved by the FDA. Always consult a qualified healthcare provider before making changes to supplements or medications.